CLEVELAND -- The last out is sometimes the most difficult to get, and Cleveland Indians starting pitcher Josh Tomlin found that out the hard way in the series finale against the Chicago White Sox at Progressive Field Thursday night.

In the top of the first inning, Tomlin allowed four straight two-out hits and the White Sox (4-4) scored five times. Then, Tomlin surrendered another two runs in the top of the second inning and was pulled from the game, which Chicago won by a 10-4 count over the Indians (4-5).

Shortstop Tim Anderson led off the game with a home run on the first pitch, but the White Sox were far from done.

After left fielder Melky Cabrera was erased by a fielder’s choice following a single to left field, right fielder Avisail Garcia smacked a single to left field. Then, third baseman Matt Davidson swung on the first pitch from Tomlin and blasted a three-run home run over the wall in right field.

Second baseman Yolmer Sanchez followed with a double to right field, and came around to score when catcher Omar Narvaez hit an RBI single to shallow left field.

Although the Indians responded with a run on a sacrifice fly from second baseman Jose Ramirez in the bottom of the first inning, the White Sox went right back to work in the top of the second.

Cabrera drew a one-out walk and first baseman Jose Abreu followed with a single to left field. After both runners moved into scoring position on designated hitter Cody Asche’s fly out to center field, Avisail Garcia sent a two-run single to center field.

The Indians scored twice in the bottom of the fifth inning when left fielder Michael Brantley belted a home run to right field, and three batters later, returning outfielder Lonnie Chisenhall drove in Ramirez with a double to right, but it was not nearly enough against Chicago.

The White Sox extended their lead over the Indians to seven runs with three straight run-producing singles from Abreu, Asche and Avisail Garcia in the top of the eighth inning. Anderson, Cabrera and Abreu scored Chicago’s runs in the frame.

The Indians got their final run of the game when catcher Yan Gomes broke out of an 0-for-3 game and 1-for-21 performance to start the season with a solo home run over the wall in left field.