The Ohio Department of Transportation says all lanes on I-480 westbound at Northfield Road have reopened.
The lanes had to be closed briefly earlier Monday after a five-vehicle crash just east of the Warrensville Heights city limit.
According to police, just before 10 a.m., traffic slowed down, causing a chain-reaction crash. One of the middle cars caught fire, spreading flames to two other vehicles.
Two people were taken to MetroHealth Medical Center with injuries described as non-life threatening. One person was treated for burns.