Police say EMS found the man, 34, lying in the road on Lakeside Avenue about 1 a.m. Saturday.
Police responded to 2100 Lakeside Avenue about 1 a.m. Saturday.
He had stab wounds to his left side and was taken to MetroHealth Medical Center where he remains.
While at the scene, officers were told that the victim takes medications for a psychiatric condition and had been chasing a female around when he was confronted by a group of men and stabbed.
The men were not at the scene when police arrived and no descriptions were given. Detectives continue to investigate.