It will offer education and family support to up to 110 children in grades K to 12.
There are classrooms where parents and teachers can observe the children, a motor skills room, a sensory room and one-on-one attention from teachers.
"These children need more intervention than their school districts can provide, so we are helping children with severe needs and, many times, the mentality of two- to three-year-olds," says PEP CEO Frank Fecser.
"I used to take my son to school and he would cry, but he loves it here," says Heather Cruz, who has an 18-year-old son at the school.
The school will also collaborate with local colleges, like Cleveland State University, and also University Hospitals.