Close Friday's winning Mega Millions numbers for October 21, 2016 WKYC Staff , WKYC 10:11 PM. EST October 21, 2016 CONNECT TWEET LINKEDIN GOOGLE+ PINTEREST Are you feeling lucky? Grab your tickets and check the numbers because you just might be holding the Mega Millions winning ticket!The winning Mega Millions numbers for Friday October 21, 2016 are: 12-43-44-48-66and the Mega Ball is 3. CONNECT TWEET LINKEDIN GOOGLE+ PINTEREST JOIN THE CONVERSATION To find out more about Facebook commenting please read the Conversation Guidelines and FAQs Leave a Comment TRENDING VIDEOS Power Plant Implosion - Tiffany Tarpley Final AM Weather For Friday, Feb 24, 2017 Ways To Save For Friday, Feb 24, 2017 Lakefront power plant smokestacks set for demolition More information on Bryon Macron Longboard Jesus at University of Akron Ravenna HS update Bullying incident at Ravenna HS Body pulled from Lake Id'd as missing trustee Man cleared in Shaker Heights murder case dies More Stories FORECAST | Record Shattering Heat Today, Snow Tomorrow! Feb 10, 2017, 8:37 a.m. Cleveland Auto Show 2017: Everything you need to know Feb 21, 2017, 11:19 a.m. John Kasich says 'no animosity' toward Donald Trump Feb 24, 2017, 3:31 p.m.