Winston-Salem, NC (Sports Network) - Top seed and last year's runner-up Tomas Berdych and two-time defending champion John Isner both pulled out of the Winston-Salem Open on Monday.
The former Wimbledon runner-up Berdych cited right shoulder pain, while the third-seeded Isner exited with a hip injury. Isner ousted Berdych in last year's finale at Wake Forest University.
The 6-foot-9 North Carolina native Isner hails from nearby Greensboro.
Isner was a runner-up against former world No. 1 star Rafael Nadal at the ATP Masters 1000 event in Cincinnati on Sunday. The surging American recently titled in Atlanta and was also a hardcourt runner-up in Washington, D.C., earlier this month.
Winston-Salem serves as a final tune-up for the U.S. Open.