The man known as "Public Enemy No. 1" is behind bars after 13 years on the run.
Many cities around the country, including Cleveland, could feel the impact of Joaquin Guzman's arrest, but for how long?
In Cuyahoga County alone last year hundreds of people died from heroin.
Nearly 70 percent of heroin is believed to have come from Chicago.
Guzman, otherwise known as "El Chapo" or "Shorty," is accused of creating a drug empire there, and building a strong-hold in Northeast Ohio.
He's evaded capture and frustrated authorities on both sides of the US Mexican border.
But an early-morning operation in Mazatlan brought it all to an end.
U.S. Attorney Steve Dettelbach says Cleveland will be impacted.
"His criminal organization has brought on ton upon ton of heroin, cocaine, illegal drugs being shipped all over the country including here in northeast Ohio," said Dettelbach.
Guzman is accused of funneling nearly a quarter of all illegal drugs into the U.S. from Mexico.
"His gang is larger, numbering in the 10s of thousands. He is more deadly and responsible for the death of over 10,000 people," said Arthur Bilek from the Chicago Crime Commission.
Guzman escaped from a high-security Mexican prison in 2001.
There are tunnels leading from a safe house to the sewer system where he used to hide and evade police.
But even with his arrest, the U.S. attorney says local authorities need to be more vigilant than ever.
"Let's not be naive about this, there are many, many other criminals and criminal organizations out there ready, willing and able to take his place so we have to stay on top of this, recognize a good victory when we have it, and we have to keep up with the problem," said Dettelbach.
Guzman is named in many indictments around the country.
The U.S. would like to have him extradited.
They want him put in a super-max prison where he can't escape again.
Some believe it's the only way to cripple his operation.