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Cleveland Browns vs. Arizona Cardinals: Preview, point spread, how to watch

The Cleveland Browns will face the Arizona Cardinals in Week 6 of the 2021 NFL season.

CLEVELAND — One week removed from their 47-42 loss to the Los Angeles Chargers (4-1), the Cleveland Browns (3-2) will face the Arizona Cardinals (5-0).

RELATED: More Cleveland Browns coverage from WKYC

What follows is everything you need to know about the Browns' Week 6 matchup:

Game info, how to watch on TV, betting line:

Date: Sunday, October 17, 2021

Time: 4:05 p.m. ET

Location: FirstEnergy Stadium in Cleveland, Ohio

TV channel: FOX

Live Stream:  FoxSports.com

Radio: ESPN 850, 92.3 The Fan, 98.5 WNCX

Betting line: Browns -3

Over-under point total: 49.5

Game preview

Entering the weekend one game back of the Baltimore Ravens in the AFC North standings, the Browns will look to get back to their winning ways after a heartbreaking loss to the Chargers. While Cleveland will be returning home, it will do so to face the NFL's lone remaining unbeaten team with Arizona entering the Week 6 contest with an impressive 5-0 record.

But while Cardinals quarterback Kyler Murray has been playing at an MVP level and possesses arguably the league's deepest wide receiving corps (DeAndre Hopkins, Christian Kirk, A.J. Green and Rondale Moore), Arizona has also been battling injuries and multiple positive COVID-19 tests. Meanwhile, the once-banged-up Browns appear to be getting healthier with wide receiver Jarvis Landry potentially making his return after missing Cleveland's previous three games due to a sprained MCL.

In order for the Browns to win, they'll have to play one of their most complete games on both sides of the ball. Based on the personnel, this matchup could be a high-scoring affair or a grind-it-out type of game with both teams keeping the ball inbounds.

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